If you are having trouble running ETQW on Win 8, please post your issue here with as much detail as possible including what solutions you have tried.
If you know of solutions OR possible solutions, please post them here to help others. You don't have to wait for a problem post, you can go ahead and post a list of common troubleshooting tips for getting software to work in Win 8.
Thanks!

if you have ETQW installed on another drive you can play it direct from that don't even install it on win8

It is an OpenGL game; most of your problems should be solved by installing the lastest drivers your graphics card from manufacturer's website.